Two sample MR report
HLA-A_Dendritic Cell (DC) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | -0.0140880 | 0.1821423 | 0.9420626 |
| Weighted median | 6 | 0.0788096 | 0.0189899 | 0.0000332 |
| Inverse variance weighted | 6 | 0.0728686 | 0.0137573 | 0.0000001 |
| Simple mode | 6 | 0.0846748 | 0.0246873 | 0.0186376 |
| Weighted mode | 6 | 0.0829691 | 0.0250363 | 0.0211483 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.492350 | 4 | 0.8279957 |
| Inverse variance weighted | 1.721578 | 5 | 0.8861702 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0315995 | 0.0660004 | 0.6570929 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 8.6e-05 | 0 | TRUE | 0.3853639 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
